Sparassis crispa given to stroke-prone spontaneously hypertensive rats as 1.5% of their feed delayed incidence of stroke and death with significantly decreased blood pressure and amelioration of cerebrovascular endothelial dysfunction1.
S. crispa fruiting body (2-5g/day).
1. Beneficial effect of Sparassis crispa on stroke through activation of Akt/eNOS pathway in brain of SHRSP. Yoshitomi H, Iwaoka E, Kubo M, Shibata M, Gao M. J Nat Med. 2011;65(1):135–141.