Hericium erinaceus has traditionally been used in the treatment of gastric ulcers and gastritis and extracts have been shown to be effective clinically and in animal models with reported inhibition rates of 70-90%1-5.
Animal experiments showed maximum efficacy at a dose of 500mg/kg and the Chinese Pharmacopoeia gives a daily dose of 25-50g for the raw mushroom.
1. Gastroprotective effects of Lion’s Mane mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) extract against ethanol-induced ulcer in rats. Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, Vikineswary S. Evid Based Complement Alternat Med. 2013;2013:492976.
2. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. Int J Med Mushrooms. 2013;15(2):165–174.
3. A double-blind study of effectiveness of Hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Xu CP, Liu WW, Liu FX, Chen SS, Liao FQ, Xu Z, Jiang LG, Wang CA, Lu XH. Chin Med J (Engl). 1985;98(6):455–456.
4. Cytoprotective effects of Hericium erinaceus on gastric mucosa in rats. Yu CG, Xu ZM, Zhu QK, Zhang ZH, Chen ZR, Sun CH, Zhang YF, Wang N. Chin J Gastroenterol. 1999:4(2):93–96.
5. Effect of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-induced gastric ulcers in rats. Abdulla MA, Noor S, Vikineswary S, Abdullah N, Wong KH, Ali HM. Int J Med Mushrooms. 2008;10(4):325–330.