In a controlled human study daily consumption of 320mg S. crispa fruiting body by healthy volunteers over a period of 28 days dramatically reduced transepidermal water loss in the treatment group with no change in the control group, indicating enhanced skin integrity, and in vivo studies show increased collagen production and enhanced wound healing from S. crispa supplementation1-3.
Although 320mg/day was shown to enhance skin integrity, higher doses may be necessary with in vivo studies showing enhanced collagen synthesis at 70mg/kg b.w.
1. Effects of medicinal mushroom (Sparassis crispa) on wound healing in streptozotocin-induced diabetic rats. Kwon AH, Qiu Z, Hashimoto M, Yamamoto K, Kimura T. Am J Surg. 2009 Apr;197(4):503-9.
2. Orally and topically administered Sparassis crispa (Hanabiratake) improved healing of skin wounds in mice with streptozotocin-induced diabetes. Yamamoto K, Kimura T. Biosci Biotechnol Biochem. 2013;77(6):1303-5.
3. Sparassis crispa (Hanabiratake) ameliorates skin conditions in rats and humans. Kimura T, Hashimoto M, Yamada M, Nishikawa Y. Biosci Biotechnol Biochem. 2013;77(9):1961-3.