Armillaria mellea exhibits anti-convulsant activity and it, as well as Gastrodia elata, a herb with which it grows symbiotically, has traditionally been used in cases of epilepsy1,2.

In-vivo and in vitro studies also indicate possible benefit of Ganoderma lucidum with polysaccharides showing anti-convulsant activity in rats and the spores showing inhibition of epileptiform discharge in hippocampal neurons3-5.

Armillaria mellea tablets used clinically in China (3-5g/day) combine mycelium with culture medium extract and can be combined with G. lucidum shell-broken spore powder (3-5g/day).

1. Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Ojemann L.M, Nelson W.L, Shin D.S, Rowe A.O, Buchanan R.A. Epilepsy & Behavior. 2006;8(2):376-383.
2. The cultivation, bioactive components and pharmacological effects of Armillaria mellea. Gao L.W, Li W.Y, Zhao Y.L and Wang J.W. Afr J Biotech. 2009;8(25):7383-7390.
3. Intervention effects of Ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin. Wang SQ et al. PLoS One. epub 2013 Apr 24;8(4):e61687.
4. Anticonvulsant and neuroprotective effects of oligosaccharides from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes). Tello I et al. Int J Med Mushrooms. 2013;15(6):555-68.
5. Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides
by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons. Wang SQ et al. PLoS One. 2014 Jul 10;9(7):e102161.